فرمت فایل: پاورپوینت - ppt  

کتاب سبز - قابل ویرایش ) 

تعداد اسلاید : 50
Drugs used in the treatment of hyperlipidemias By S.Bohlooli, PhD Introduction Introduction Used to prevent or slow progression of atherosclerosis to reduce the risk of coronary artery disease and prolong life Cholesterol Advantages Serves as a component of cell membranes and intracellular organelle membranes Is involved in the synthesis of certain hormones including estrogen, progesterone, testosterone, adrenal corticosteroids Needed for the synthesis of bile salts which are needed for digestion and absorption of fats. Introduction Cholesterol Advantages Is deposited in the stratum corneum of the skin to help ↓ evaporation of water and create impermeability to water soluble compounds (helps keep moisture in skin) Origin Is synthesized in the liver. Acetyl CoA is converted to mevalonic acid and ultimately to cholesterol by hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase. Introduction Cholesterol Origin Endogenous synthesis of cholesterol increases at night An increase in dietary cholesterol produces only a small ↑ in blood levels of cholesterol because ingestion inhibits endogenous synthesis Dietary saturated fats ↑ blood cholesterol levels because they are converted to cholesterol in the body. Introduction Lipoproteins Serve as carriers for transporting lipids (cholesterol and triglycerides) in the blood. Apolipoproteins Embedded in the lipoprotein shell Three functions 1. Serve as recognition sites for cell-surface receptors; allowing cells to bind and ingest the lipoprotein. 2. Activate enzymes that will metabolize the lipoprotein 3. ↑ structural stability of the lipoprotein Introduction Introduction Introduction Introduction Introduction Introduction The major pathways involved in the metabolism of chylomicrons synthesized by the intestine and VLDL synthesized by the liver Classification of Plasma Lipid Levels Secondary Causes of Dyslipidemia Treatment of hyperlipidemia Treatment of hyperlipidemia Niacin: chmeistry Antilipemic agents Antilipemic agents Antilipemic agents Antilipemic agents Antilipemic agents Antilipemic agents Fibrates: chemistry Antilipemic agents Antilipemic agents Antilipemic agents Antilipemic agents Antilipemic agents Bile Acid-Binding Resins :chemistry Antilipemic agents Antilipemic agents Antilipemic agents Antilipemic agents chemistry Antilipemic agents Antilipemic agents Antilipemic agents Antilipemic agents Antilipemic agents Antilipemic agents Antilipemic agents Antilipemic agents Ezetimibe:chemistry Antilipemic agents Inhibitors of Cholesteryl Ester Transfer Protein

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